Air Pollution May Exacerbate Lewy Body Dementia Risk

A study of 56 million people reveals a link between long-term exposure to PM2.5 air pollution and an increased risk of developing Lewy body dementia. The research suggests PM2.5 doesn't cause the disease but accelerates its onset in genetically predisposed individuals. Experiments in mice showed PM2.5 exposure led to α-synuclein buildup in the brain, alongside impaired spatial memory and object recognition. The study also indicates PM2.5 might spread α-synuclein via the gut-brain axis, contributing to Lewy body dementia.